The pharmacologic effects of zidovudine may be lowered because of enhanced non-hepatic or renal clearance of zidovudine.
Assess patients for signs of diminished diuresis and/or effects on blood pressure and increase the dosage of the diuretic as necessary.
The oxycodone in oxycodone and acetaminophen tablets may perhaps cause spasm of your sphincter of Oddi. Opioids may perhaps cause improves in serum amylase. Watch patients with biliary tract disease, together with acute pancreatitis, for worsening symptoms.
Taking prescription or over-the-counter medicines, vitamins, or herbal dietary supplements. Using oxycodone and acetaminophen tablets with certain other medicines can cause major side effects that can bring on death. When taking oxycodone and acetaminophen tablets:
Watch patients closely for respiratory melancholy, Particularly within the first 24 to seventy two several hours of initiating therapy and subsequent dosage will increase with oxycodone and acetaminophen tablets and regulate the dosage appropriately [see WARNINGS].
Infants subjected to oxycodone and acetaminophen tablets by breast milk must be monitored for excess sedation and respiratory despair. Withdrawal symptoms can take place in breastfed infants when maternal administration of an opioid analgesic is stopped, or when breastfeeding is stopped.
These effects may be extra pronounced with concomitant use of oxycodone and acetaminophen tablets and CYP3A4 and CYP2D6 inhibitors, specifically when an inhibitor is extra after a steady dose of oxycodone and acetaminophen tablets is realized [see WARNINGS].
Opioid antagonists, such as naloxone, are specific antidotes to respiratory depression ensuing from opioid overdose. For clinically significant respiratory or circulatory despair secondary to opioid overdose, administer an opioid antagonist. Because the duration of opioid reversal is predicted being a lot less than the duration of action of oxycodone in oxycodone and acetaminophen tablets, carefully watch the patient right up until spontaneous respiration is reliably reestablished.
After halting a CYP3A4 inhibitor, as being the effects in the inhibitor decline, the oxycodone plasma focus will reduce [see CLINICAL PHARMACOLOGY], causing decreased opioid efficacy or simply a withdrawal syndrome in patients who experienced created Actual physical dependence to PERCOCET.
If the choice is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the bottom effective dosages and minimum amount durations of concomitant use. In patients currently getting an opioid analgesic, prescribe a lower First dose with the benzodiazepine or other CNS depressant than indicated during the absence of an opioid, and titrate determined by clinical reaction.
Intense Hypotension PERCOCET might cause significant hypotension together with orthostatic hypotension and syncope in ambulatory patients. There's enhanced risk in patients whose capacity to maintain blood pressure has presently been compromised by a minimized blood quantity or concurrent administration of sure CNS depressant drugs (e.
Infertility Inform patients that use of opioids for an extended period of time may cause lessened fertility. It is far from known whether these effects on fertility are reversible [see ADVERSE REACTIONS].
Check these patients intently, particularly when initiating and titrating oxycodone and acetaminophen tablets and when oxycodone and acetaminophen tablets are offered concomitantly with other drugs that depress respiration [see WARNINGS; LIFE THREATENING RESPIRATORY Melancholy]. Alternatively, consider the usage of non-opioid analgesics in these patients.
The concomitant usage percocet insomnia of oxycodone and acetaminophen tablets with all cytochrome P450 3A4 inhibitors may lead to an increase in oxycodone plasma concentrations, which could raise or prolong adverse reactions and could cause potentially fatal respiratory depression.